近年来,含铜的避孕器使用有所增加,但它是引起许多病人月经血量增多的原因。作者选择15例月经周期相同要求的避孕妇女,作二次宫内膜活检,第一次活检在按放避孕器前,第二次活检是在按放避孕器后最少三个月。她们是年龄在16—26岁之间、妇科检查正常、一年内末妊娠也末经口服避孕药的健康妇女。用pandolfi改良的Todd组织化学方法来测定宫内膜纤维蛋白溶解活性。标本用迅速膨胀的CO_2作快速冷冻。在标本检查前,将其密封在保护膜内以防干燥,并保存在零下60℃,用低温槽切片机将标本切成8微米厚,置于清洁的载玻片上,每个标本作4张切片,每张切片上的标本均覆以0.06毫升的纤维蛋白原和10微升的凝血 In recent years, copper-containing contraceptive use has increased, but it is caused by many patients increased menstrual flow. The author chose 15 cases of women with the same requirements of the menstrual cycle contraceptives for second endometrial biopsy, the first biopsy before placing the IUD, the second biopsy is in place after I put the IUD at least three months. They are healthy women between the ages of 16 and 26 with normal gynecological examinations and no contraceptive pills at the end of one year. Endometrial fibrinolytic activity was determined using the modified Todd histochemistry of pandolfi. Specimens were rapidly frozen with rapidly expanding CO 2. Prior to specimen examination, seal it in a protective film to prevent it from drying out and store at minus 60 ° C. Cut the specimen into 8 μm thick using a cryostat microtome and place it on a clean glass slide with 4 specimens per specimen Slides, each section of the specimen were covered with 0.06 ml of fibrinogen and 10 microliters of coagulation